Title: Professor, Principle Investigator

Teaching: Pharmacology

Research Interests：

The lab is focusing on developing new techniques to reverse aging. Currently, several new aging speeding models have been established in the lab, and a couple of compounds against aging have been uncovered. Also, the compounds show potent activity for preventing and treating aging associated diseases, including type 2 diabetes and its complications, skin wrinkles, gastric ulcers and so on.

Besides compounds, engineered tissues or cells will be applied to conquer aging and aging related diseases, and “body renew” would be turned into reality.      

Research experience

University of Notre Dame, USA, 2017-2018

Purdue University, USA, 2013-2017

University of Illinois, Chicago, USA, 2012

Peking University, China, 2009-2011

National University of Singapore, Singapore, 2007-2008

Grants

       1.The Fundamental Research Funds for the Central Universities, Lanzhou University, 2020-2021

       2.Collaborative investigation with Taiyuan Company, Gansu, 2019

       3."Double First-Class" initiative, Lanzhou University, 2018-2021

4. Epigenetic Regulation of Gene Expression in the Aging Eye, RO1, NIH, 2015-2020

5. Cytoskeletal mechanisms of retinal development, RO1, NEI, 2011-2015

6. Misregulation of Stress-induced Gene Expression in the Aging Eye, Ralph W. and Grace M. Showalter Research Trust, Purdue University, 2014-2015

7. Postdoctoral funding (20090460157), Chinese postdoctoral funding agency, 2009

Honor and Awards

2000 Excellent undergraduate, Sichuan University

Representative Publications:

1. Xinping Chen, Hana Hall, Jeffrey Simpson, Walter Leon-Salas, Donald Ready, Vikki Weake. Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration. npj Aging and Mechanisms of Disease. 2017, 3, 18.

2. Xinping Chen, Walter D.Leon-Salas, Taylor Zigon, Donald F.Ready, Vikki M.Weake. A programmable optical stimulator for the Drosophila eye. HardwareX. 2017, 2, 13-33.

3. Xinping Chen, Chunyue Zhao, Xiaolong Li, Tao Wang, Yizhou Li, Cheng Cao, Yuehe Ding, Mengqiu Dong, Lorenzo Finci, Jia-huai Wang, Xiaoyu Li, Lei Liu. Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nat. Chem. Biol. 2015,11, 19-25.

4. Xinping Chen, Yan Li, Junbo Huang, Dawei Cao, Guoying Yang, Weijie Liu, Huimin Lu, Aike Guo. Study of tauopathies by comparing Drosophila and human tau in Drosophila. Cell. Tissue. Res. 2007, 329, 169-178.

5. Xinping Chen, Graeme K Carnegie. Cell proliferation depends on the direct binding between PKM2 and AKAP-Lbc. bioRxiv 2017, doi: https://doi.org/10.1101/103333

6. Matthew C. Pharris, Tzu-Ching Wu, Xinping Chen, Xu Wang, David M.Umulis, Vikki M.Weake, Tamara L.Kinzer-Ursem. An automated workflow for quantifying RNA transcripts in individual cells in large data-sets. MethodsX. 2017, 4, 279-288.

7. Guiping Du, Xiang Liu, Xinping Chen, Mei Song, Yan Yan, Renjie Jiao, Chih-chen Wang. Drosophila histone deacetylase 6 protects dopaminergic neurons against alpha-Synuclein toxicity by promoting inclusion formation. Mol. Biol. Cell. 2010, 21, 2128–2137.

8.Jingjing Liu, Wenyang Zhao, Chun Li, Tongyu Wu, Liang Han, Zhuozhou Hu, Xiangxiang Li, Jing Zhou and Xinping Chen. Terazosin Stimulates Pgk1 to Remedy Gastrointestinal Disorders. Int. J. Mol. Sci. 2022, 23, 416.

Patient application:

    陈新平、吴桐雨、李纯、周静、赵文阳。一种快速筛选抗糖化和/或抗衰老物质的方法，发明专利，2019年10月受理。