Full Name: Zhi-Jun Zhang

Position: Associate Professor

E-mail: zhangzj@lzu.edu.cn; zhangzhijun198803@163.com

Address: School of Pharmacy, Lanzhou University, Lanzhou, Gansu, 730000, China

Education:

Sep. 2014-Jul. 2018

Ph.D. degree at South China Agricultural University, Major in pesticide syntyesis

Sep. 2011-Jul. 2014

MSc. degree at Lanzhou University, Major in medicinal chemistry

Professional Background:

Jan. 2023~present

Associate Professor,

School of Pharmacy, Lanzhou University

Aug. 2018-Jul. 2023

Lecturer, School of Pharmacy, Lanzhou University

Courses:

Organic chemistry (for undergraduate students)

Textbook:

< Organic chemistry >, People’s Medical Publishing House, Jun. 2022

Research experience

Responsible for research projects: “the Program of National Natural Science Foundation of China (32302390)”, “the Natural Science Foundation of China Gansu Province (20JR5RA216) ” and “ the Fundamental Research Funds for the Central Universities (lzujbky-2019-27, lzujbky-2022-37)”.

Research Interests

Design, synthesis and mechanism study of new antimicrobial agents based on natural active molecules.

Representative Publications:

1) Jiang Shao1, Zhi-Jun Zhang1, Yu Shi, Wei-Qi Jiang, Faisal Siddique, Liangye Chen, Genyan Liu, Jiakai Zhu, Xiong-Fei Luo, Ying-Qian Liu*, Jun-Xia An, Cheng-Jie Yang, Zi-Ning Cui*. Application and Mechanism of Cryptolepine and Neocryptolepine Derivatives as T3SS Inhibitors for Control of Bacterial Leaf Blight on Rice. Journal of Agricultural and Food Chemistry, 2024. doi: 10.1021/acs.jafc.4c00214.

2) Tian-Lin Wu, Bao-Qi Zhang, Xiong-Fei Luo, An-Ping Li, Shao-Yong Zhang, Jun-Xia An, Zhi-Jun Zhang*, Ying-Qian Liu*. Antifungal efficacy of sixty essential oils and mechanism of oregano essential oil against Rhizoctonia solani. Industrial Crops and Products, 2023, 191, 115975.

3) Hai-Xin Li, Xiong-Fei Luo, Peng Deng, Shao-Yong Zhang, Han Zhou, Yan Yan Ding, Yi-Rong Wang, Ying-Qian Liu*, and

Zhi-Jun Zhang*

. Structural Simplification of Cryptolepine to Obtain Novel Antifungal Quinoline Derivatives against Phytopathogenic Fungi. Journal of Agricultural and Food Chemistry, 2023, 71, 2301-2312.

4) Yan-Yan Ding, Yu Sun, Xiong-Fei Luo, Shao-Yong Zhang, Rui Wang, Zhi-Gang Yang*, Jing-Ru Wang, Bao-Qi Zhang, Zhi-Jun Zhang*, Yue Ma, Jun-Xia An, Han Zhou, Ying-Qian Liu*. Anti-phytopathogenic activity and the mechanisms of phthalides from Angelica sinensis (Oliv.) Diels. Pest Management Science, 2023, 79, 2135-2146.

5) Yan-Yan Ding, Han Zhou, Peng-Deng, Bao-Qi Zhang, Zhi-Jun Zhang*, Guang-Han Wang, Shao-Yong Zhang*, Zheng-Rong Wu, Yi-Rong Wang, Ying-Qian Liu.* Antimicrobial activity of natural and semi-synthetic carbazole alkaloids. European Journal of Medicinal Chemistry, 2023, 259, 115627.

6) Yong Zhou, Yin-Peng Bai, Mi Zhang, Jian-Mei Gao, Cheng-Jie Yang, Zhi-Jun Zhang*, Nan Deng, Lei Li, Ying-Qian Liu*, Chuan-Rui Xu*. Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors. Bioorganic Chemistry, 2022, 122, 105747.

7) Yin-Peng Bai, Cheng-Jie Yang, Nan Deng, Mi Zhang, Zhi-Jun Zhang*, Lei Li, Yong Zhou, Xiong-Fei Luo, Chuan-Rui Xu*, Bao-Qi Zhang, Yue Ma, Ying-Qian Liu. Design and synthesis of novel 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives as potential high selectivity and low toxicity topoisomerase I inhibitors for hepatocellular carcinoma. Biochemical Pharmacology, 2022, 200, 115049.

8) Yong Zhou, Cheng-Jie Yang, Xiong-Fei Luo, An-Ping Li, Shao-Yong Zhang, Jun-Xia An, Zhi-Jun Zhang*, Yue Ma, Bao-Qi Zhang, Ying-Qian Liu*. Design, synthesis, and biological evaluation of novel berberine derivatives against phytopathogenic fungi. Pest Management Science, 2022, 78 (10), 4361-4376.

9) Junmin Xi1, Zhijun Zhang1, Zuo Wang1, Qingfeng Wu, Ying He, Yanyi Xu, Zhenjiang Ding, Huanhuan Zhao, Honghong Da, Fang Zhang, Haiyu Zhao*, Jianguo Fang*. Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection. Free Radical Biology and Medicine, 2022, 190, 202-215.

10) Yue Ma, Rui Zhou, Xiong-Fei Luo, An-Ping Li, Rui Wang, Bao-Qi Zhang, Han Zhou, Tian-Lin Wu, Yi-Rong Wang, Jun-Xia An, Zhi-Jun Zhang*, Wen-Bin Zhao, Cheng-Jie Yang, Yan Yan Ding, Ying-Qian Liu*. Inhibition of Fusarium graminearum growth and deoxynivalenol biosynthesis by phenolic compounds. ChemistrySelect, 2022, 7 (43), e202201546.

11) Xiao-Fei Shang, Li-Xia Dai, Zhi-Jun Zhang*, Cheng-Jie Yang, Sha-Sha Du, Tian-Lin Wu, Ying-Hui He, Jia-Kai Zhu, Ying-Qian Liu*, Yin-Fang Yan, Xiao-Lou Miao, and Ji-Yu Zhang. Integrated proteomics and transcriptomics analyses reveals the possible antifungal mechanism of an indoloquinoline alkaloid neocryptolepine against Rhizoctonia solani. Journal of Agricultural and Food Chemistry, 2021, 69, 6455−6464.

12) Hu Li, Ying-Hui He, Yong-Mei Hu, Qing-Ru Chu, Yong-Jia Chen, Zhen-Rong Wu, Zhi-Jun Zhang*, Ying-Qian Liu*, Cheng-Jie Yang, Hong-Jie Liang, Yin-Fang Yan, Design, synthesis, and structure−activity relationship studies of magnolol derivatives as antifungal agents. Journal of Agricultural and Food Chemistry, 2021, 69, 11781−11793.

13) Yu-Dong Yang, Ying-Hui He, Kun-Yuan Ma, Hu Li, Zhi-Jun Zhang*, Yu Sun, Yu-Ling Wang, Guan-Fang Hu, Ren-Xuan Wang, and Ying-Qian Liu*, Design and discovery of novel antifungal quinoline derivatives with acylhydrazide as a promising pharmacophore. Journal of Agricultural and Food Chemistry, 2021, 69, 8347−8357.

14) Yong-Jia Chen, Kun-Yuan Ma, Sha-Sha Du, Zhi-Jun Zhang*, Tian-Lin Wu, Yu Sun, Ying-Qian Liu*, Xiao-Dan Yin, Rui Zhou, Yin-Fang Yan, Ren-Xuan Wang, Ying-Hui He, Qing-Ru Chu, and Chen Tang, Antifungal exploration of quinoline derivatives against phytopathogenic fungi inspired by quinine alkaloids. Journal of Agricultural and Food Chemistry, 2021, 69, 12156−12170.

15) Anping Li, Zhongmin Zhao, Shaoyong Zhang, Zhijun Zhang*, Yanping Shi*, Fungicidal activity and mechanism of action of glabridin from Glycyrrhiza glabra L. International Journal of Molecular Sciences, 2021, 22, 10966.

16) Yin-Fang Yan, Tian-Lin Wu, Sha-Sha Du, Zheng-Rong Wu, Yong-Mei Hu, Zhi-Jun Zhang*, Wen-Bin Zhao, Cheng-Jie Yang, Ying-Qian Liu*, The antifungal mechanism of isoxanthohumol from Humulus lupulus Linn. International Journal of Molecular Sciences, 2021, 22, 10853.

17) Ren-Xuan Wang, Sha-Sha Du, Jing-Ru Wang, Qing-Ru Chu, Chen Tang, Zhi-Jun Zhang*, Cheng-Jie Yang, Ying-Hui He, Hai-Xing Li, Tian-Lin Wu, and Ying-Qian Liu*, Design, synthesis, and antifungal evaluation of luotonin A derivatives against phytopathogenic fungi. Journal of Agricultural and Food Chemistry, 2021, 69, 14467-14477.

18) Ying-Hui He, Xiao-Fei Shang, Hai-Xin Li, An-Ping Li, Chen Tang, Bao-Qi Zhang, Zhi-Jun Zhang*, Rui Wang, Yue Ma, Sha-Sha Du, Yong-Mei Hu, Tian-Lin Wu, Wen-Bin Zhao, Cheng-Jie Yang, Ying-Qian Liu*, Antifungal activity and action mechanism study of coumarins from Cnidium monnieri fruit and structurally related compounds. Chemistry & Biodiversity, 2021, 18, e2100633.

19) Zi-Long Song, Guan-Zhou Yang, Jun-Cai Li, Ying-Qian Liu*, Chen-Jie Yang, Masuo Goto, Zhi-Jun Zhang*, Susan L. Morris-Natschke, Hua Liu, Kuo-Hsiung Lee*, Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents. Natural Product Research, 2020, 34, 2022-2029.

20) Zhi-Jun Zhang, Xiao-Fei Shang, Liu Yang, Yan-Bin Shi, Ying-Qian Liu*, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Engineering of peglayted camptothecin into nanomicelles and

supramolecular hydrogels for pesticide combination control. Frontiers in Chemistry, 2020, 7, 922.

21) Jie Zeng, Zhijun Zhang*, Qi Zhu, Zhiyan Jiang, and Guohua Zhong*, Simplification of natural β-carboline alkaloids to obtain indole derivatives as potent fungicides against rice sheath blight. Molecules 2020, 25, 1189.

22) Guan-Zhou Yang, Xiao-Fei Shang, Pi-Le Cheng, Xiao-Dan Yin, Jia-Kai Zhu, Ying-Qian Liu*, Jing Zhang*, and Zhi-Jun Zhang*, Facile three-component synthesis, insecticidal and antifungal evaluation of novel dihydropyridine derivatives. Molecules, 2018, 23, 2422.

23) Zhi-Jun Zhang, Zhi-Yan Jiang, Qi Zhu, Guo-Hua Zhong*. Discovery of β-carboline oxadiazole derivatives as fungicidal agents against rice sheath blight. Journal of Agricultural and Food Chemistry, 2018, 66, 9598-9607.

24) Zhi-Jun Zhang, Yong Zeng, Zhi-Yan Jiang, Ben-Shui Shu, Veeran Sethuraman, Guo-Hua Zhong*. Design, synthesis, fungicidal property and QSAR studies of novel β-carbolines containing urea, benzoylthiourea and benzoylurea for the control of rice sheath blight. Pest Management Science, 2018, 74, 1736-1746.

25) Jing-Jing Zhang1, Zhi-Jun Zhang1, Ben-Shui Shu, Gao-Feng Cui, Guo-Hua Zhong*. Cytotoxic and apoptotic activity of a novel harmine derivative ZC-14 in Sf9 cells. International Journal of Molecular Sciences, 2018, 19, 811.

26) Junmin Xi1, Zhijun Zhang1, Qi Zhu and Guohua Zhong*, Evolution from natural β-carboline alkaloids to obtain 1,2,4,9-tetrahydro-3-thia-9-aza-fluorene derivatives as potent fungicidal agents against Rhizoctonia solani. International Journal of Molecular Sciences, 2018, 19, 4044.

27) Zhi-Jun Zhang, Jing-Jing Zhang, Zhi-Yan Jiang, Guo-Hua Zhong*. Design, synthesis and bioactivity evaluation of novel β-carboline 1,3,4-oxadiazole derivatives. Molecules 2017, 22, 1811.

28) Wen-Qun Li1, Zhi-Jun Zhang1, Xiang Nan, Ying-Qian Liu*, Guan-Fang Hu, Hai-Tao Yu, Xiao-Bo Zhao, Dan Wu and Li-Ting Yan. Design, synthesis and bioactivity evaluation of novel benzophenone hydrazone derivatives. Pest Manag. Sci. 2014, 70, 667-673.

29) Zhi-Jun Zhang, Jing Tian, Li-Ting Wang, Mei-Juan Wang, Xiang Nan, Liu Yang, Ying-Qian Liu*, Susan L. Morris-Natschke and Kuo-Hsiung Lee*. Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin. Bioorg. Med. Chem. 2014, 22, 204-210.

30) Liu Yang1, Zhi-Jun Zhang

1, Ying-Qian Liu*, Chun-Yan Zhao, Mei-Juan Wang, Xiang Nan, Gang Feng*. Evaluation of insecticidal activity of camptothecin analogs against Brontispa longissima. Med. Chem. Res. 2014, 23, 980-986.