Full Name: Xiuxia Sun

Position: Associate Professor

E-mail: sxx@lzu.edu.cn

Address: School of Pharmacy, Lanzhou University, Lanzhou, Gansu, 730000, China

Education:

Sep. 2016-Jul. 2019

Ph.D. degree at Lanzhou University, Major in Analytical Chemistry

Sep. 2013-Jul. 2016

MSc. degree at Lanzhou University, Major in Chemical Engineering

Professional Background:

Jan. 2022~present

Associate Professor of Pharmaceutics, School of Pharmacy, Lanzhou University

Aug. 2019-Jul. 2021

Postdoctoral of Biology, School of Life Sciences, Lanzhou University

Courses:

Pharmaceutics (for undergraduate students)

Textbook:

< Pharmaceutics >, People’s Medical Publishing House, Jun. 2023

Research Interests:

Research experience

Responsible for and participate in research projects: “the Program of National Natural Science Foundation of China”

Research Interests

1.Bioanalytical Chemistry: Designing and screening fluorescent peptide probes capable of selectively recognizing key protein biomarkers enables highly specific and sensitive fluid detection, while exploring their applications in disease diagnostics;

2.Peptide-based Biomaterials: Constructing self-assembling peptide systems with precisely controlled sequences to mimic the structure and function of the extracellular matrix expands their applications in tissue engineering and regenerative medicine;

3.Protein-based Biomaterials: Development of protein preparation and cross-linking techniques for innovating high biocompatible next-generation medical materials.

Representative Publications:

1)Lifang Wang, Haijiao Wang, Jingjing Niu, Honggang Chen, Meng Wang, Zhigang Yang, Shaohua Wang, Xiuxia Sun* and Yanbin Shi*; Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action, European Journal of Pharmacology, 2024, 5(966): 176348.

2)Xiuxia Sun; Siqi Quan; Bo Wang; Qi Wang; Wenhua Li; Jianxi Xiao*; Peptide-triggered self-assembly of collagen mimetic peptides into nanospheres by electrostatic interaction and p-p stacking, Journal of Materials Chemistry B, 2023, 11(21): 4677-4683.

3)Jianan Li, Wenjie Huang, Huixia He, Shuangni Shi, Xiuxia Sun* and Jianxi Xiao*; Biocompatible and bioactive hydrogels of recombinant fusion elastin with low transition temperature for improved healing of UV-irradiated skin, Journal of Materials Chemistry B, 2023, 11(29): 6975-6982.

4)Jean Claude Munyemana, Huixia He, Caihong Fu, Yirui Fan, Xiuxia Sun* and Jianxi Xiao*; Recombinant Collagen-Templated Biomineralized Synthesis of Biocompatible pH-Responsive Porous Calcium Carbonate Nanospheres, ACS Omega, 2023, 8(34): 30879-30887.

5)Caihong Fu, Shanshan Zhang, Fan Yang, Ximing Chen* and Xiuxia Sun*; Calcium and Sodium-mediated Dynamic Assembly of Intermediate Filament-like Protein Filp, Protein & Peptide Letters, 2023, 30(2),154-161.

6 Caihong Fu, Wenhua Li, Xiuxia Sun* and Jianxi Xiao*; Concentration-mediated Folding and Unfolding of Collagen Triple Helix, Protein & Peptide Letters, 2023, 30(1): 85-91.

7)Xiuxia Sun, Wenhua Li, Jingyuan Yu, Liting Luo, Jie Wang, Jianxi Xiao*; Ln3+ -triggered self-assembly of a heterotrimer collagen mimetic peptide into luminescent nanofibers, Chemical Communications, 2020, 56(96), 15141-15144.

8)Xiuxia Sun, Yan Qiao, Wenhua Li, Yiyao Sui, Yiyan Ruan, Jianxi Xiao*; A graphene oxide-aided triple helical aggregation-induced emission biosensor for highly specific detection of charged collagen peptide, Journal of Materials Chemistry B, 2020, 8(28), 6027-6033.

9)Xiuxia Sun, Zhao Liu, Sha Zhao, Xiaojun Xu, Shenlin Wang, Chengchen Guo, Jianxi Xiao*; A self-assembling collagen mimetic peptide system to simultaneously characterize the effects of osteogenesis imperfecta mutations on conformation, assembly and activity, Journal of Materials Chemistry B, 2019, 7, 3201-3209.

10)Xiuxia Sun, Linyan Yao, Caihong Fu, Liting Luo, Jie Wang, Jianxi Xiao*; Detection of target collagen peptides with single amino acid mutation using two fluorescent peptide probes, Journal of Materials Chemistry B, 2019, 7(48), 7676-7682.

11)Xiuxia Sun, Manman He, Lang Wang, Liting Luo, Jie Wang, Jianxi Xiao*; Luminescent Biofunctional Collagen Mimetic Nanobers, ACS Omega, 2019, 4(15), 16270-16279.

12)Xiuxia Sun, Jun Fan, Caihong Fu, Linyan Yao, Sha Zhao, Jie Wang, Jianxi Xiao*; WS2 and MoS2 biosensing platforms using peptides as probe biomolecules, Scientific Reports, 2017, 7(1), 10290.

13)Xiuxia Sun, Jun Fan, Yannan Hou, Shuo Liang, Yuping Zhang, Jianxi Xiao*; Fluorescence characterization of the thermal stability of collagen mimic peptides, Chinese Chemical Letters, 2017, 28, 963-967.

14)Xiuxia Sun, Jun Fan, Xuan Li, Shanshan Zhang, Xiaoyan Liu, Jianxi Xiao*; Colorimetric and fluorometric monitoring of the helix composition of collagen-like peptides at the nM level, Chemical Communications, 2016, 52(15), 3107-3110.

15)Xiuxia Sun, Jun Fan, Yuping Zhang, Hongli Chen, Yongqing Zhao, Jianxi Xiao*; A graphene oxide-based FRET sensor for rapid and specific detection of unfolded collagen fragments, Biosensors and Bioelectronics, 2016, 79, 15-21.

16)Xiuxia Sun, Jun Fan, Weiran Ye, Han Zhang, Yong Cong, Jianxi Xiao*; A highly specific graphene platform for sensing collagen triple helix, Journal of Materials Chemistry B, 2016, 4(6), 1064-1069.

17)Xiuxia Sun, Songqing Liu, Wenyuan Yu, Shaoru Wang, Jianxi Xiao*; CD and NMR investigation of collagen peptides mimicking a pathological Gly-Ser mutation and a natural interruption in a similar highly charged sequence context, Protein Science, 2016, 25(2), 383-392.

18)Xiuxia Sun, Yalin Chai, Qianqian Wang, Huanxiang Liu, Shaoru Wang, Jianxi Xiao*; A natural interruption displays higher global stability and local conformational flexibility than a similar Gly mutation sequence in collagen mimic peptides, Biochemistry, 2015, 54(39), 6106-6113.

19)Xiuxia Sun, Xiangdong Cai, Renqi Wang, Jianxi Xiao*; Immobilized trypsin on hydrophobic cellulose decorated nanoparticles shows good stability and reusability for protein digestion, Analytical Biochemistry, 2015, 477, 21-27.

20)Jianxi Xiao, Xiuxia Sun, Balaraman Madhan, Barbara Brodsky* and Jean Baum*. Hydrogen bonding at the natural interruption sites in Type IV collagen drives the formation of single-component heterotrimer collagen peptides, Journal of Biological Chemistry, 2015, 290(40), 24201-24209.

21)Jianxi Xiao, Zhangfu Yang, Xiuxia Sun, Rayna Addabbo* and Jean Baum*; Local amino acid sequence patterns dominate the heterogeneous phenotype for the collagen connective tissue disease Osteogenesis Imperfecta resulting from Gly mutations, Journal of Structural Biology, 2015, 192(1):127-137.