Full Name: Sanhu Gou 

Position: Ph.D, Associate Professor 

E-mail: gousanhu@lzu.edu.cn 

Address: School of Pharmacy, Lanzhou University. No.199 Donggang West Road, Lanzhou 730000, P. R. China 

Education: 

Sep. 2016~Jun. 2019

Ph.D. degree at School of Basic Medical Sciences, Lanzhou University, Major in Clinical Discipline of Chinese and Western Integrative Medicine

Sep. 2013~Jun. 2016

M.S. degree at School of Pharmacy, Lanzhou University, Major in Pharmaceutics

Sep.2009~Jun. 2013

B.S. degree at School of Life Science, Northwest Normal University, Major in Pharmaceutical engineering 

Professional Background: 

Jun. 2022~present

Associate Professor, School of Pharmacy, Lanzhou University

Jul. 2019~May. 2022

Postdoctoral, Academician Wang Rui Research Group, Biology Postdoctoral Mobile Station, Lanzhou University 

Teaching Courses: 

Pharmaceutics, Biopharmaceutics and Pharmacokinetics, Pharmaceutical Apparatus and Technology 

Research experience： 

Sanhu Gou is an associate professor and postgraduate tutor in the School of Pharmacy of Lanzhou University. He is also a member of the Key Laboratory of Preclinical Research for New Drugs of Gansu Province and the " Research Unit of Peptide Science" of the Chinese Academy of Medical Sciences. Young editor of Journal of Lanzhou University (Medical Edition). Presided over the China Postdoctoral Science Foundation, one National Natural Science Foundation of China, and Science and Technology Plan Foundation of Gansu Province. In recent years, he has published more than 30 papers in the Journal of Medicinal Chemistry, British Journal of Pharmacology and other top pharmaceutical journals. 

Research Interests：

1.The development of active peptide drugs with new structures and new drug delivery systems based on peptides

2.The development of active ingredient products new dosage forms and new formulations of natural medicines. 

Representative Publications: 

1.Gou S.; Liu J.; He M.; Ni J*., Quantification and bio-assay of α-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch[. Natural Product Research 2016, 30(18):2130-2134.

2.Gou S.; Huang H.; Chen XY.; …& Ni J.,* Lipid-lowering, hepatoprotective, and atheroprotective effects of the mixture Hong-Qu and gypenosides in hyperlipidemia with NAFLD rats[J]. Journal of the Chinese Medical Association 2016, 79(3):111-121.

3.Gou, S.; Liu, B.; Han, X.; Wang, L.; Zhong, C.; Liang, S.; Liu, H.; Qiang, Y.; Zhang, Y.; Ni, J*., Anti-atherosclerotic effect of Fermentum Rubrum and Gynostemma pentaphyllum mixture in high-fat emulsion- and vitamin D3-induced atherosclerotic rats. Journal of the Chinese Medical Association 2018, 81 (5), 398-408.

4.Gou, S.; He, M.; Li, BB.; Zhu, N.; & Ni, J*. Hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis Fisch in liver injury mice. Natural Product Research 2020. DOI：10.1080/14786419.2020.18242233

5.Gou, S.; Wang, L.; Zhong, C.; Chen, X.; Ouyang, X.; Li, B.; Bao, G.; Liu, H.; Zhang, Y.; Ni, J*., A novel apoA-I mimetic peptide suppresses atherosclerosis by promoting physiological HDL function in apoE-/-mice. British Journal of Pharmacology 2020, 177 (20), 4627-4644. 

6.Gou, S.; Li, B.; Ouyang, X.; Ba, Z.; Zhong, C.; Ni, J*., Tuning the Activity of Anoplin by Dendrimerization of Lysine and Lipidation of the N-Terminal. Acs Omega 2021, 6 (33), 21359-21367.

7.Gou, S.; Li, B.; Ouyang, X.; Ba, Z.; Zhong, C.; Zhang, T.; Chang, L.; Zhu, Y.; Zhang, J.; Zhu, N.; Zhang, Y.; Liu, H.; Ni, J*., Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice. Journal of Medicinal Chemistry 2021, 64 (15), 11247-11266.

8.Li, B.; Ouyang, X.; Ba, Z.; Yang, Y.; Zhang, J.; Liu, H.; Zhang, T.; Zhang, F.; Zhang, Y.; Gou, S*.; Ni, J*., Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. Journal of Medicinal Chemistry 2022, 65 (7), 5625-5641.

9.Ouyang, X.; Li, B.; Yang, Y.; Ba, Z.; Zhang, J.; Zhang, T.; Chang, L.; Zhang, F.; Zhang, Y.; Liu, H.; Gou, S*.; Ni, J*., Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies. Journal of Medicinal Chemistry 2022, 65 (20), 13833-13851.

10.Li, B.; Ouyang, X.; Liu, Y.; Ba, Z.; Yang, Y.; Zhang, J.; Yang, P.; Yang, T.; Wang, Y.; Zhao, Y.; Mao, W.; Zhong, C.; Liu, H.; Zhang, Y.; Gou, S*.; Ni, J*., Novel β-Hairpin Antimicrobial Peptide Containing the β-Turn Sequence of -NG- and the Tryptophan Zippers Facilitate Self-Assembly into Nanofibers, Exhibiting Excellent Antimicrobial Performance. Journal of Medicinal Chemistry 2024. https://doi.org/10.1021/acs.jmedchem.3c02339